National Grand Rounds - October 2025
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Element 64 (Gadolinium): The Lee Harvey Oswald of Cellular Biology
Join ACMT on Tuesday, October 7, 2025, at 12 PM ET for an exclusive National Grand Rounds featuring Dr. Brent Wagner. A leading expert in nephrogenic systemic fibrosis and gadolinium retention, Dr. Wagner will share insights from his groundbreaking research on Gadolinium Deposition Disease, a condition linked to the use of MRI contrast agents in patients with impaired renal function. This session will explore the clinical implications, pathophysiology, and evolving understanding of gadolinium-related complications.
Learning Objectives
- Identify the physiological elemental composition of the milieu intérieur, (and realize that gadolinium is alien to it).
- Examine the diagnostic criteria for ‘nephrogenic’ systemic fibrosis (and realize that neither renal insufficiency nor gadolinium exposure are required)
- Describe The Albuquerque Hypothesis as presented: Magnetic resonance imaging contrast agents are degraded into gadolinium-rich nanoparticles (in accordance with Le Chatelier’s Principal) intracellularly. These intracellular rare earth metal-laden sediments may explain the constellation of complications.
About The Series: ACMT's Grand Rounds offer an in-depth and interactive platform for learning and discussion about issues that impact the research and practice of medical toxicology. Experts from within and outside medical toxicology will share their knowledge and experience and highlight areas for collaboration and mutual understanding.
This webinar is for ACMT members only.
Brent Wagner, MD, MS
Director, Kidney Institute of New Mexico; Professor of Medicine, Division of Nephrology
University of New Mexico Health Science Center
Dr. Wagner is a nephrologist and clinical researcher specializing in kidney disease and medical safety. He serves as Medical Director at DCI Cuba and directs the Kidney Institute of New Mexico. As a professor at UNM’s Health Sciences Center, his work has focused on complications arising from medical treatments, with a particular emphasis on contrast-induced kidney injury and gadolinium-related toxicities.
Nicholas E. Nacca, MD, FACMT (Moderator)
Assistant Professor of Emergency Medicine, Director of Medical Toxicology, Fellowship Director of Medical Toxicology Fellowship Program
University of Rochester Medical Center
Dr. Nicholas Nacca is the director of Medical Toxicology and Medical Toxicology Fellowship Director at the University of Rochester Medical Center. In addition to being faculty member in the Department of Emergency Medicine he holds a secondary appointment in the Department of Environmental Medicine. His primary role is staffing the educational and clinical medical toxicology consultation service, with educational responsibilities to medical toxicology fellows, multidisciplinary teams of medical residents, pharmacy residents and students, as well as medical students. He staffs and directs a referral based outpatient Medical Toxicology Clinic.
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